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The wealth of data resources on human phenotypes, risk factors, molecular traits and therapeutic interventions presents new opportunities for population health sciences. These opportunities are paralleled by a growing need for data integration, curation and mining to increase research efficiency, reduce mis-inference and ensure reproducible research. We developed EpiGraphDB (https//epigraphdb.org/), a graph database containing an array of different biomedical and epidemiological relationships and an analytical platform to support their