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These methods have been mainly supplanted by immunohistochemical treatments with monoclonal antibodies directed against special constituents among these cellular kinds. Immunohistochemistry with antibodies specific for the granule protease tryptase provides an even more painful and sensitive and discriminating means for finding mast cells than utilizing the ancient histochemical treatments, and making use of antibodies particular for services and products of basophils (2D7 antigen and basogranulin