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05), suggesting that frequent practice of tai chi chuan may slow the rate of knee degeneration.Aim The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials methods Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse transcriptase PCR. Results The upregulation of hsa_circ_0004771 was correlated with heavier tumor burden and poor prognosis, kn