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Porcine epidemic diarrhea virus (PEDV) triggers severe diarrhoea and large death in neonatal suckling piglets, resulting in significant economic losses to the swine business. Currently there are not any adequate control methods against circulating PEDV variants, making an urgent need to take advantage of result antiviral treatments to pay for vaccines. Here, we report that Aloe plant can hamper totally the proliferation of PEDV at