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Two number of N-substituted indole derivatives for example. N-substituted indole based chalcones (12a-g) and N-substituted indole based hydrazide-hydrazones (18a-g, 19a-f, 21 a-g) were synthesized. The synthesized substances had been characterized by 1H NMR, 13C NMR, Mass and FT-IR spectral data. More these types were assessed for his or her antimicrobial potential against Escherichia coli, Bacillus subtilis, Pseudomonas putida and Candida viswanathii, and
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