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These results demonstrate that the acceptors with nearly identical absorption spectra could result in a significant difference in photovoltaic performance, which stress the importance of end-capping units. Furthermore, few NFA-based devices achieve large Voc and high Jsc simultaneously as one based on PM6BDTN-BF, indicating that nitrogen hybridization of NFAs may be an efficient strategy to realize high and balanced Voc and Jsc.Traditional results from toxicogenomics studies are complex lists of significantly impacted genes or gene sets