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A total of 113 (8%) and 84 (7%) participants developed dementia and AD. Comparing to participants with high GFR (≥ 80 ml/min/1.73m ), participants with low ( 67 ml/min/1.73m ) and moderate GFR (67 ≤ GFR 80 ml/min/1.73m ) had increased risk of incident dementia with hazard ratios (HRs) of 1.87 (95% CI 1.02-3.44) and 2.19 (95% CI 1.21-3.95) after adjustment for confounders, respectively. Low (HR = 2.27 [95%CI 1.10-4.68]) and moderate (HR = 2.14 [95% CI 1.04-4.40]) GFR at baseline was also independently associated with incident AD