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At Pearson's analysis, the first shape mode was positively correlated to both the end-diastolic volume (p less then 0.01, R=0.814) and end-systolic volume (p less then 0.01, and R=0.922), suggesting LV impairment in patients with severe AS. A predictive model built with PCA-related shape modes achieved better performance in stratifying the occurrence of adverse events with respect to a baseline model using clinical demographic data as risk predictors. This study demonstrated the potential of SSA approaches to detect the association of c
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