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© 2020 The Authors. Published by WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.ICAM-1 is a cell area glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from blood supply to web sites of infection. Nonetheless, as well as vascular endothelial cells, ICAM-1 expression is also robustly caused on epithelial and resistant cells as a result to inflammatory stimulation. Importantly, ICAM-1 serves as a biosensor to transduce outside-in-signaling via relationship