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Apoptotic myonuclei were present in muscle with limited intrusion, but not into the invaded fibres. Fibres with TUNEL positive nuclei had been surrounded by CD8+ T-cells, granzyme B+ cells and macrophages, but lacked FAS receptor phrase. On the other hand, apoptotic myonuclei were unusual in dermatomyositis and absent in controls. The conclusions confirm that apoptosis occurs in idiopathic inflammatory myopathies and assistance it is mediated by CD8+ cytotoxic T- cells, acting in parall
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