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genes) validated for this microarray did not reveal any sex differences. However, sex differences might be observed for other gene targets. The cascades of processes initiated in the vasculature following reperfusion are complex. Dynamic gene expression alterations were observed in the occluded MCAs, and to a less pronounced degree in the non-occluded MCAs. Dysregulation of inflammation and blood-brain barrier breakdown are possible pharmacological targets. The sample of genes ( less then 1% of the differentially expressed genes) validate