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In contrast, RVSE treatment dramatically increased the expression of PAI-1. These results indicate that the inhibition of MMP-9 and uPA expression and STAT3 phosphorylation and the stimulation of PAI-1 expression contributed to the decreased migration and invasion of AGS cells treated with RVSE. These results suggest that RVSE may be used as a natural herbal agent to reduce gastric cancer metastasis. These results suggest that RVSE may be used as a natural herbal agent to reduce gastric cancer metastasis. (PG), an oriental herbal medic
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