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In conclusion, reduced activity of SPPL2a protease in monocytes from AS predisposes to endosomal accumulation of CD74 and CD74 N-terminal fragments, which, upon IFNγ-exposure, is deposited at the plasma membrane and can be recognized by anti-CD74/CLIP autoantibodies. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.The burden of obesity and other chronic diseases negatively affects the nation's health, businesses, economy, and military readiness. The prevalence is