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In addition, we also found that heparan sulfate proteoglycan (HSPG) families were lineage-specifically expanded in C. hongkongensis and abundantly expressed in phagocytes. Efficiency of phagocytosis and hemocytes aggregation was markedly reduced upon blockage of endogenous synthesis of HSPGs, thus implicating these proteins as key surface receptors in pathogen recognition and initiation of phagocytosis. Copyright © 2020 Lin, Mao, Wong, Zhang, Liu, Huang, Ma, Xiang, Li, Xiao, Zhang and Yu.Introduction Severe Combined Immunodeficiency (S
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