https://www.selleckchem.com/products/GDC-0449.html
4±11.8, 42.8±21.8 and 66.6±39.1. Emergence of resistance as indicated by 2 log growth on MICx8 recovery media was maximal at AUC/MIC ratios of 10-40 and was suppressed at AUC/MIC ratios of ≥250. CONCLUSIONS The dominant PDI for fosfomycin against S.aureus are Cmax/MIC in terms of reduction of bacterial load and AUC/MIC in terms of suppressing emergence of resistance. AUC/MIC ratios of 20-75 are associated with a -1 log reduction in bacterial load and AUC/MIC of 10-40 maximally increase emergence of resistance. V.Clostridium diffici
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