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Moreover, a significant increase in the fragmented DNA was evident in exposed groups relative to the control one. Granzyme B protein levels showed a significant increase concerning control. A wide variety of adverse human health risks are considered a potential risk to Egyptian uranium miners. For employers working in both mining and processing fields, the most common molecular shift highlighted was the leucocyte damage in blood samples. To preserve the health of all employees, health education and administration of effective hazard management procedures ar