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How Does Medication For ADHD Work? Stimulants increase your ability to concentrate and control impulses by increasing the levels of dopamine and norepinephrine in your brain. They are available in both immediate-release (short acting) and extended release tablets, which can be taken once daily in the morning. Nonstimulant medicines take longer to work but can also improve concentration and control of impulses. Atomoxetine (Strattera) and Guanfacine (Viloxazine) are both in the class of antidepressants and increase levels of norepinephrine