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Exploring new materials is an eternal pursuit in the development of human civilization [...].The problem of controlling a spreading process in a two-layer multiplex networks in such a way that the extinction state becomes a global attractor is addressed. The problem is formulated in terms of a Markov-chain based susceptible-infected-susceptible (SIS) dynamics in a complex multilayer network. The stabilization of the extinction state for the nonlinear discrete-time model by means of appropriate adaptation of system parameters like transi