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63 times the rate of meningitis as non-IBD comparators. After adjusting for relevant covariates among those with IBD, treatment with mesalamine was associated with a significantly lower odds of a meningitis claim (odds ratio 0.40, 95% confidence interval 0.26-0.62). Having at least one comorbidity was associated with a significantly higher odds of a meningitis claim (odds ratio 2.21, 95% confidence interval 1.76-2.77). Conclusions Although the overall rate of meningitis is low, IBD patients are at an increased risk compared with non-IBD