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Does ADHD Medication Work? When someone is given a prescription for ADHD medication, they often be concerned about whether the medication will be effective and how long it will last. Here are some simple answers. Stimulants work by adjusting levels of brain chemicals that send messages about the level of attention and activity. Dopamine, norepinephrine and other brain chemicals are also included. They are considered the first-line treatment option for adults suffering from ADHD. 1. Stimulants Stimulants