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ADHD Medications For Adults Stimulants can help regulate levels of chemical messengers in the brain that control attention. They are regarded as the first-line treatment for ADHD. believed to be habit-forming, however they can trigger negative side effects, including headache and trouble sleeping. To reduce impulsivity or hyperactivity, your doctor may prescribe guanfacine with the brand names Tenex or Intuniv (Catapres). These drugs are more effective than stimulants. Stimulants Stimulants