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Incorporation of new treatment modalities has significantly increased the complexity of the treatment and management of rectal cancer, including perioperative therapy for local advanced disease and organ preservation for those with response to the preoperative treatment. This review may help practitioners better understand the rationale and selection.Objective This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis.Methods ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western