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In this study, galactose-grafted beads were prepared using the main design principle of the cluster effect. Galactose was chosen as the sugar for investigation because it acts as the main building block of long glycan chains and because a simple and fast protocol is still required for its immobilization. For the analysis, the lectin, ligand of the galactose, was immobilized on a gold plasmonic substrate. After preliminary characterization of the galactose-grafted beads, the investigation of the surface plasmon surface behavior of the sy