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6% for chemo (n=957), and -71.7% and -45.3% for anti-VEGF (n=1355). The optimal AUC cutoff for differentiating PD from non-PD on first restaging was -7.5% for chemo and -62.0% for anti-VEGF, chemo, ORadj=6.51 (95%CI 3.31-12.83, P less then 0.001); anti-VEGF, ORadj=3.45 (95%CI 1.93-6.18, P less then 0.001). A 99% NPV clinical cutoff for prediction of non-PD would avoid CT scan at first restaging in 21.0% of chemo and 16.2% of anti-VEGF treated patients. Among patients with SD on first restaging, those with CEA decrease from baseline ha