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e., ~20.0 °C. The random forest model can predict relative humidity with a 1.1% mean absolute deviation compared to the values obtained through Aspen HYSYS. The performance of the RF estimation model is also compared with a well-known support vector regression model. The random forest model demonstrates 74.4% better performance than the support vector machine model for the problem of interest, i.e., relative humidity estimation. This study will significantly help the practitioners in efficient designing of air-dependent energy systems