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Experimental in vitro biological studies confirmed that studied compounds demonstrated high inhibition of HBV replication in 10 µM concentration.Rapid urban expansion often leads to substantial encroachment on ecological lands and destruction of natural environments. We developed a new cellular automata model (named CACEO) that uses cross-entropy optimization (CEO) to reproduce and project urban expansion into coastal areas and to assess urban encroachment on ecological lands. The CEO algorithm automatically searches for the near-optimal C