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13. In conclusion, a two-layer probabilistic model for predicting COPD exacerbations can increase classification rates compared to a one-layer model, and to a level of clinical relevance, for patients in telehealth. Electromoxibustion devices are commercially available and can be self-administered by patients. Nevertheless, little is known about the effectiveness and potential burn injury of these devices as this topic is under-investigated. To assess the preliminary effects and safety of an electromoxibustion (EM) device for improving k