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86, 95% CI 0.80-0.91) or later (AUC 0.90, 95% CI 0.84-0.96), achieving AR diagnosis with an AUC of 0.85 and 0.92 (P less then 0.0001) in two external validation cohorts. Decision curve analyses demonstrated the clinical utility of the model. Considering confounding factors rather than excluding them, we optimized a noninvasive multiparametric diagnostic model for AR of kidney allografts with unprecedented accuracy. This article is protected by copyright. All rights reserved.BACKGROUND While the quality of medical care delivered by physi