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How Does ADHD Medication Work? The medications can reduce ADHD symptoms by increasing levels of the chemicals noradrenaline and dopamine that pass messages between brain cells. The most frequently prescribed stimulants are methylphenidate, atomoxetine and glycine. Finding the right medication and dose will require a lot of trial and trial and. Your doctor's communication with you should be open and honest. Stimulants The stimulant medications prescribed for ADHD increase levels o