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Health Issues That Affect German Shepherd Life Expectancy German Shepherds reach their peak between ages 2 and 6. The German Shepherd is at its best in terms of mental and physical sharpness. Their size makes them at a higher chance of developing cancer, musculoskeletal issues, and other health issues that could affect their lifespan. German Shepherds in the working line usually lead more active lives than their show line counterparts. They require a diet high in nutrients to sustain their active lifestyles and exercise. Cushing's Disease German Shepherds are