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Pooled odds ratio for risk of cancer among opium users for the 11-case control study was 3.85 (2.18-6.79). Heterogeneity was high (I-squared=92.0%, Tau-squared=0.88). There was no publication bias in the study. Subgroup analysis showed highest OR for pooled estimate for risk of laryngeal cancer (19.98 (11.04-36.15)). There was almost four-fold rise in risk of head and neck cancer among opium users compared to non-users. There was almost four-fold rise in risk of head and neck cancer among opium users compared to non-users. Selective or R
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