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The current study was undertaken to analyze the consequence of moscatilin, a bibenzyl by-product through the orchid Dendrobium loddigesii on human melanoma cells. In A375 cells substance moscatilin showed a definite dose-response relationship in the number of 6.25-50 μM concentrations. In inclusion, we demonstrated an apoptotic reaction after remedy for cancer tumors cells with this specific bibenzyl substance at 6.25 and 12.5 μM concentrations that probably requires PTEN activity, inhibition of Hsp70 appearance and