https://www.selleckchem.com/pr....oducts/CP-690550.htm
Several microbial toll-like receptor (TLR) ligands, bacterial DNA and bacterial cell wall fragments have been identified in the synovium of rheumatoid arthritis (RA) patients, proving bacterial involvement in the pathogenesis of RA. The current study aimed to verify that low dose polymyxin B could prevent the development of chronic inflammatory arthritis. Twelve days post adjuvant injection, Sprague-Dawley rats were treated twice weekly with methotrexate (0.5mg/kg) or daily with polymyxin B (1mg/kg) or with combination of both for 1 o
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