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Immunohistochemical examination of aquaporin-5 showed significant difference between the two groups. CONCLUSION bone marrow derived stem cell treatment considers as an improved methods in prevention and treatment of diabeticinduced hyposalivation. © 2020 Craniofacial Research Foundation. Published by Elsevier B.V. All rights reserved.Smoking in young adulthood is a risk factor for future health-related disabilities and a cause of expanding health inequalities. Education and smoking are inversely associated. Using population-based repres