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Pathology in immunocompetent pets coincided with weakly neutralizing antibodies and increased ADE among ZIKV strains (PRVABC59, FLR, and MR766) and all sorts of Dengue virus (DENV) serotypes. These antibodies had been autoreactive to GBS-associated gangliosides. This study highlights the importance of longevity studies in ZIKV disease and confirms the role of anti-ganglioside antibodies in ZIKV-induced neuro-ocular illness.LGBTQ individuals disproportionally encounter a v