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BACKGROUND Colorectal cancer (CRC) is one of the most prevalent tumors worldwide. Recently, long noncoding RNAs (lncRNAs) have been shown to influence tumorigenesis and tumor progression by acting as competing endogenous RNAs (ceRNAs). It is difficult to extract prognostic lncRNAs and useful bioinformation from most ceRNA networks constructed previously. AIM To construct a prognostic related ceRNA regulatory network and lncRNA related signature based on risk score in CRC. METHODS RNA transcriptome profile and clinical information of 506