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Hepatocellular carcinoma (HCC) can usually be treated effortlessly if recognized at an earlier stage. Suggested surveillance methods for at-risk patients feature ultrasound with or without α-fetoprotein (AFP), but their susceptibility is suboptimal. We sought to build up a novel, blood-based biomarker panel with improved sensitivity for early-stage HCC recognition. In a multicenter, case-control research, we obtained blood specimens from clients with HCC and age-ma