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Furthermore, THUMPD3 is widely expressed in mouse tissues, with an extremely high level in the testis. THUMPD3-knockout cells exhibited impaired global protein synthesis and reduced growth. Our data highlight the significance of the tRNA m2G6/7 modification and pave a way for further studies of the role of m2G in sperm tRNA derived fragments. Structure and protein-starch interactions in pasta products may be responsible for lower postprandial glycemic responses compared with other cereal foods. We tested the effect on postprandial glucos