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001). In VAT, HFD reduced mRNA levels of IGF2 (p less then 0.05), PAPP-A (p less then 0.001) and stanniocalcin (STC)-1 (p less then 0.001) in males. HFD increased hypothalamic IGF1 (p less then 0.01), IGF2 (p less then 0.05) and IGFBP5 (p less then 0.01) mRNA levels, with these changes more apparent in females. Our results show that diet-induced changes in the IGF system are tissue-, sex- and diet-dependent.Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inf