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The C-C motif chemokine ligand-2 (CCL2) was evidenced to be associated with tuberculosis susceptibility in some ethnic groups. In the present study, effort was made to find out the association of CCL2-2518 AG and -362 GC variants with susceptibility to TB in a population from North India. The genotyping was carried out in 373 participants with pulmonary TB (PT and 248 healthy controls (HCs) for CCL2-2518 AG and -362 GC polymorphisms by PCR-RFLP and by melting curve analysis using fluorescence-labeled hybridization fluo