https://www.selleckchem.com/pr....oducts/ziritaxestat.
Strikingly, follicles lacking Ctnnb1 failed to develop beyond the primary stage. These results show that RSPO2 acts in a paracrine manner to sustain granulosa cell proliferation in early developing follicles. Taken together, our data demonstrate that the activation of WNT/CTNNB1 signaling by RSPO2 is essential for oocyte-granulosa cell interactions that drive maturation of the ovarian follicles and eventually female fertility.Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown
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