https://www.selleckchem.com/pr....oducts/importazole.h
Myeloid-derived suppressor cells (MDSCs) play key roles in sepsis, but whether the bone marrow is considered the only source remains unclear. The current knowledge about the mechanism of MDSCs leading to myocardial injury in sepsis is poor. In sepsis patients with cardiac dysfunction, the circulating percentage of CD14 CD11b and serum concentrations of IL-6 and IL-1β were measured. A mouse sepsis model was established through caecum ligation and puncture (CLP). Animals were divided into four groups control, sham, CLP and CLP+splenec
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