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Moreover, the permeation-promoting outcomes of the CEO on both hydrophobic and hydrophilic components were tested via in vitro epidermis penetration experiments as well as in vivo microdialysis experiments. The outcome suggested the capability associated with the CEO to improve the dwelling associated with the SC, leading to improved transdermal permeation of hydrophobic and hydrophilic ingredients. The 1.5% CEO team demonstrated the best permeation-promoting impact when compared to va