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How Does Medication For ADHD Work? The majority of people notice that their symptoms improve when they take a medication. Finding the right medication at the right dose takes time, open communication and patience with your GP. The medicines that treat ADHD adjust the levels of chemical messengers in the brain. Stimulant medicines, like methylphenidate, can help you focus and reduce hyperactivity and impulsivity. Atomoxetine and guanfacine are nonstimulant drugs that improve behavior and reduce the