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IMPACT STATEMENTWhat is already known on this subjects? Spexin is a newly identified peptide hormone which plays various roles in regulating energy metabolism and the hypothalamic gonadal axis. PCOS is a reproductive and metabolic disorder associated with insulin resistance and hypothalamic-pituitary-gonadal axis disruptions.What do the results of this study add? Decreased levels of spexin were inversely association with androgens and unfavourable metabolic profiles in PCOS women. The risk of having PCOS was increased in parallel with de
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