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The RevMan 5.4 software will be used for statistical analysis. This study will provide the latest evidence for acupuncture combined with analgesics to relieve LC pain. The conclusion of this study is to evaluate the effectiveness and safety of acupuncture combined with analgesics in alleviating LC pain. INPLASY202150051. INPLASY202150051. Diabetic peripheral neuropathy (DPN) is one of the most common microvascular complications of diabetes mellitus, with an incidence ranging from 60% to 90%. With the change in modern dietary structure,