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This article reviews key population trends affecting rural American health. The article explains the role of demography in defining and studying rural health using example data from the 2014 to 2018 American Community Survey. Specific trends, including depopulation, aging, racial/ethnic diversification, socioeconomic status, and health characteristics found in rural areas, are highlighted. Insights are offered into how population trends, changing age and sex structures, and socioeconomic distributions have implications for rural