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Climate change manifestation in the ocean, through warming, oxygen loss, increasing acidification and changing particulate organic carbon flux (one metric of altered food supplies), is projected to affect most deep-ocean ecosystems concomitantly with increasing direct human disturbance. Climate drivers will alter deep-sea biodiversity and associated ecosystem services, and may interact with disturbance from resource extraction activities or even climate geoengineering. We suggest that to ensure the effective management of increasing use