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ADHD Treatment For Adults The stimulants like methylphenidate amphetamine, and other brain chemicals can aid in increasing levels. Nonstimulants, such as atomoxetine and antidepressants, work slower than stimulants but they can be beneficial too. Complicating conditions can impact the effectiveness of ADHD medication. The most serious symptom of any comorbid condition must be treated first. Then, the physician must be able to determine if ADHD symptoms improve. Medication Medication