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Aims Interleukin-13 (IL-13) is a Th2-associated cytokine that typically induces gut contractility and mucus secretion to eliminate helminth parasites from the digestive tract. Little evidence exists of IL-13's direct effect on Haemonchus contortus larvae (L3), and thus were the objective of this study. Methods To test effects of IL-13 on H. contortus, L3 were treated with ovine recombinant (r)IL-13 (1 μg/ml); motility and morbidity were assessed. Monocytes isolated from H. contortus-resistant St. Croix (STC) and -susceptible Suffolk (SU